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Mohan, Arti
- Formulation and Evaluation of Immediate Release Film Coated Tablets of An Anticancer Drug (Dasatinib)
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Authors
Arti Mohan
1,
G. Sangeetha
2
Affiliations
1 Depatment of Pharmaceutics, Krupanidhi College of Pharmacy, IN
2 Department of Pharmaceutics, Gautham College of Pharmacy, Bengaluru, Karnataka, IN
1 Depatment of Pharmaceutics, Krupanidhi College of Pharmacy, IN
2 Department of Pharmaceutics, Gautham College of Pharmacy, Bengaluru, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 729-734Abstract
Aim: The objective of the present study was to develop an immediate release tablet of Dasatinib using different concentration of superdisintegrants with a view to obtain rapid action for myelogenous leukemia and acute lymphoblastic leukemia[1]. Dasatinib is a chemotherapy medication used to treat certain cases of leukaemia. Materials and Methods: Various formulations were prepared by direct compression technique using super disintegrants (cross carmellose sodium, sodium starch glyclote and crospovidone). Effect of different superdisintegrants on drug release was studied. Optimized formulation was selected on the basis of drug release and its in-vitro release profile compared with the reference product (Sprycel). Results and Discussion: The dissolution results showed gradient increase in the drug release with the increase in concentration of the super-disintegrants. Conclusion: Among all the formulations F3 containing croscarmellose sodium (4.5%) was found to show best results with 98.3% release within 45 minutes and it exhibited a release profile comparable to the reference product.Keywords
Dasatinib, Myelogenous Leukemia, Croscarmellose Sodium, Direct Compression Technique, Immediate Release.References
- B. Rasmitha Reddy, B.Venkateswara Reddy, K.Navaneetha. Formulation and evaluation of Dasatinib immediate release tablets, World Journal of Pharmacy and Pharmaceutical Sciences 2014; 3(3): 1113-1123.
- Kamath AV, Wang J, Lee FY, Marathe PH. Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL. Cancer Chemother Pharmacol 2008; 61(3):365-76.
- Sai Madhav Reddy K, Laxmidhar Sahoo, Kamalakar Reddy G, Vamsi Krishna L., ‘Formulation and evaluation of immediate release tablets of Linezolid.’ Int. J. Pharm and Bio Arch 2011; 2 (4): 1230-1235.
- Malthi kodithyala et al. Formulation and Evaluation of dasatinib floating microsphers, IJIPSR 2014; 2(9):2086-2105
- Rakesh P. Patel and Nitish Thakker. Studies in development of dasatinib nanoformulations, European Journal of Pharmaceutical and Medical Research 2016; 3(7):423-432.
- Chinmaya keshari sahoo, Muvvala sudhakar, Satyabrata bhanja, Uttam Prasad Panigrahy, Kanhucharan Panda. Development and evaluation of immediate release tablets of dasatinib using sodium starch glycolate as super disintegrant. Innoriginal International Journal of Sciences 2017; 4(1):4-7.
- Abdel Naser Zaid, Salam Natour, Aiman Qaddomi and Abeer Abu Ghoush. Formulation and in vitro and in vivo evaluation of film-coated montelukast sodium tablets using Opadry® yellow 20A82938 on an industrial scale, Drug Des Devel Ther 2013; 7: 83–91.
- Jain A, Gupta DMK, Sharma V. Formulations and evaluation of film coated immediate release tablets of piracetam. Journal of Biomedical and Pharmaceutical Research [Internet]. 24 Jan.2018[cited 6Apr.2018];7(1). Available from: http://jbpr.in/index.php/jbpr/article/view/507
- Chinmaya keshari sahoo and D. Venkataramana. Formulation and Evaluation of Immediate release Tablets of Dasatinib using Croscarmelose sodium. Research Journal of Pharmacy and Technology 2017; 10(3):833-838.
- Christopher LJ, Donghui Cui, Chiyuan Wu, Roger Luo, Manning JA, Bonacorsi SJ, Michael Lago, Alban Allentoff, Lee FYF, Betty McCann, Susan Galbraith, Reitberg DP, Kan He, Anthony Barros, Anne Blackwood-Chirchir, Griffith Humphreys W, and Iyer RA. Metabolism and Disposition of Dasatinib after Oral Administration to Humans. Drug metabolism and disposition 2008; 36 (7): 1357–1364.
- A.K. Das, S. Bhanja, N. Srilakshmi. Formulation and evaluation of quetiapine immediate release film coated tablets , Asian Journal of Pharmaceutical and Clinical Research 2013; 6(3):107-112.
- Formulation and Evaluation of Interpenetrating Polymer Network Microparticles of Diclofenac Sodium
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Authors
Affiliations
1 Professor (Pharmaceutics), Arihant School of Pharmacy and Bio Research Institute, Adalaj, Gandhinagar,, IN
2 Assistant Professor, Dayanand Sagar University, Bangalore,, IN
1 Professor (Pharmaceutics), Arihant School of Pharmacy and Bio Research Institute, Adalaj, Gandhinagar,, IN
2 Assistant Professor, Dayanand Sagar University, Bangalore,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 792-798Abstract
Diclofenac sodium, a model anti-inflammatory drug, has adverse effects like gastric irritation and hepatic toxicity. To overcome these problems Interpenetrating Polymer Network microparticles can be used as a controlled drug delivery system. Preparation of Interpenetrating Polymer Network microparticles using two or more polymer is a novel approach as the polymers produce synergistic effect which could increase the mechanical strength and resilience of the microparticles. The aim of the study was to prepare Interpenetrating Polymer Network microparticles of Diclofenac Sodium using chitosan and Ghatti gum which were used to deliver Diclofenac Sodium to the intestine. Microparticles prepared by emulsion-cross-linking method using gluteraldehyde as a cross-linker were characterized by Fourier Transform Infrared Spectroscopy, Differential scanning calorimetry, Scanning electron microscopy and evaluated for in vitro dissolution rate. Fourier Transform Infrared Spectroscopy studies confirmed the absence of chemical interactions between drug, polymers and cross-linking agent. Differential scanning calorimetric results indicated amorphous dispersion of Diclofenac Sodium into Interpenetrating Polymer Network matrix. Scanning electron microscopy pictures showed that microparticles did not agglomerate and had a rough surface. Hydrated surface after swelling showed spongy porous surface which indicated the mechanism of drug release as diffusion. Particle size ranged between 294 to 366 μm. DS percentage encapsulation efficiency ranged from 84.09 to 96.81%. In vitro release studies indicated a dependence of drug release rates on both the amount of CS and GG used in preparation of microparticles. The release was extended up to 12 h and release rates indicated a non-Fickian and super case II mechanism.Keywords
Chitosan, Ghatti gum, Interpenetrating polymer networks, Microparticles, Hydrophillic polymers.References
- Bin W et al, Preparation, characterization and controlled release investigation of interpenetrating polymer networks of poly(acrylic acid)/triazole modified poly (vinyl alcohol), International Journal of Pharmaceutics, 2007; 331(1): 19–26.
- Kallappa M Hosamani, Ramesh Babu V, Malladi Sairam, Tejraj M Aminabhavi, Preparation of sodium alginate-methylcellulose blend microspheres for controlled release of Nifedipine, Carbohydrate polymers, 2007; 69(2): 241-50.
- Tejraj M. Aminabhavi, Mahaveer D Kurkuri, Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pHsensitive microspheres for the delivery of Diclofenac sodium to the intestine, Journal of Controlled Release, 2004; 96(1):9–20.
- Sperling, L. H, Interpenetrating Polymer Networks and Related Materials, Plenum Press, 1981, Chpt. 1.
- Chunhua Yin, Lichen Yin, Likun Fei, Fuying Cui, Cui Tang, Superporous hydrogels containing poly (acrylic acid-coacrylamide)/ O-carboxymethyl chitosan interpenetrating polymer networks, Biomaterials, 2007; 28(6): 1258–66.
- Ajit P Rokhade, Sunil A Agnihotri, Sangamesh A Patil, Nadagouda N Mallikarjuna, Padmakar V Kulkarni, Tejraj M Aminabhavi, Semi-interpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of Ketorolac tromethamine, Carbohydrate Polymers, 2006; 65(3): 243–2.
- Tejraj M Aminabhavi, Sangamesh A Patil, Ajit P Rokhade, Namdev B Shelke, Novel interpenetrating polymer network microspheres of chitosan and methylcellulose for controlled release of Theophylline, Carbohydrate polymers, 2007; 113(4): 678-687.
- Elworthy PH, George TM, The Molecular properties of Ghatti gum: A naturally occurring Polyelectrolyte, J Pharm Pharmcol, 1963; 15(1): 781-93.
- Tischer CA, Iacomini M, Wagner R, Gorin PA, New structural features of the polysaccharide from gum ghatti. Carbohydrate Res, 2002; 337(21-23): 2205-10.
- P A Todd E, M Sorkin, Diclofenac sodium: A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy, Drugs, 1988; 35(3): 244-85.
- Tejraj A, Sunil A, Novel interpenetrating network chitosanpoly( ethylene oxide-g-acrylamide) hydrogel microspheres for the controlled release of capecitabine, International Journal of Pharmaceutics, 2006; 324(2): 103–115.
- Rapolu B, Vedavathi T, Formulation and Evaluation of Sumatriptan Succinate Oral Disintegrating Tablets and Comparision of disintegrating property between superdisintegrants and simple disintegrants, TPI Journal, 2012; 1(9): 73-92.
- Keyur Patel, Mandev B Patel, Preparation and evaluation of chitosan microspheres containing Nicorandil, International Journal of Pharmaceutical Investigation, 2014; 4(1): 32-7
- Priya P, Mane D Formulation and Evaluation of Microspheres of Glibenclamide by Ionotropic Gelation Method, Indo American Journal of Pharmaceutical Research, 2017; 7(09): 471-79.
- Gohel M and Amin A, Formulation design and optimization of modified-release microspheres of Diclofenac sodium, Drug Development and Industrial Pharmacy, 1999, 25(2): 247–51.
- Reddy J, Gnanaprakash K, Badrinath A, Chetty C, Formulation and Evaluation of Microparticles of Metronidazole, J. Pharm. Sci. & Res, 2009; 1(10): 131-36
- Khonsari F, Milani P, Jelvehgarid M, Formulation and Evaluation of In-vitro Characterization of Gastic-Mucoadhesive Microparticles/Discs Containing Metformin Hydrochloride, Iran J Pharm Res, 2014; 13(1): 67–80.
- Balwierz R, Jankowski A, Jasinska A, Marciniak D, Pluta J, Formulation and evaluation of microspheres containing Losartan potassium by spray-drying technique, Acta Pol Pharm, 2016; 73(5): 1275-86.
- Madan R, Kadam V, Bandavane S, Dua K, Formulation and evaluation of microspheres containing Ropinirole hydrochloride using biodegradable polymers, Asian J Pharm, 2013; 7(4): 184-8.
- Misirli Y, Oeztuerk E, Kursakligolu H, Denkbas E, Preparation and characterization of Mitomycin-C loaded chitosan-coated alginate microspheres for chemoembolization, J.Microencapsule, 2005; 22(2): 167-78.
- Sriamornsak P, Nunthanid J, Calcium pectinate gel beads for controlled release drug delivery: I. Preparation and in vitro release studies, International Journal of Pharmaceutics, 1998; 160(2): 207-12.
- Peppas A, Analysis of fickian and non-fickian drug release from polymers, Pharm Acta Helv, 1985; 60(4): 110-1.
- Korsmeyer R, Gurny R, Doelker E, Buri P, Peppas N, Mechanisms of potassium chloride release from compressed hydrophilic polymeric matrices: effect of entrapped air, J Pharm Sci, 1983; 72(10): 1189-91.
- Paulo C, Jose S, Modeling and comparison of dissolution profiles, Eur J Pharm Sci, 2001; 13(2): 123-33. 25. ICH Harmonized Tripartite Guidelines, 2003. Stability testing of New Drug Substances and Products. Q1A (R2).